The Alpha Chain of the Nascent Polypeptide-Associated Complex Functions as a Transcriptional Coactivator
نویسندگان
چکیده
منابع مشابه
Nascent polypeptide-associated complex protein prevents mistargeting of nascent chains to the endoplasmic reticulum.
We show that, after removal of the nascent polypeptide-associated complex (NAC) from ribosome-associated nascent chains, ribosomes synthesizing proteins lacking signal peptides are efficiently targeted to the endoplasmic reticulum (ER) membrane. After this mistargeting, translocation across the ER membrane occurs, albeit less efficiently than for a nascent secretory polypeptide, perhaps because...
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Previous studies demonstrated that the SAGA (Spt-Ada-Gcn5-Acetyltransferase) complex facilitates the binding of TATA-binding protein (TBP) during transcriptional activation of the GAL1 gene of Saccharomyces cerevisiae. TBP binding was shown to require the SAGA components Spt3 and Spt20/Ada5, but not the SAGA component Gcn5. We have now examined whether SAGA is directly required as a coactivator...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 1998
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.18.3.1303